Research positions in computational neuroscience

Applications are invited for research positions in the Neuroinformatics Group of the Department of Integrative Neurophysiology, VU University Amsterdam.

*** modeling neurite outgrowth and network formation ***
The positions are funded by the EU-FP7 grant for the Collaborative Large-scale Integrating Project Self-Constructing Computing Systems (SECO). Using a combined computational and experimental approach, the SECO project aims to investigate the principles by which populations of real or artificial neurons grow out and assemble themselves into functioning neural circuits.
Our group participates in the SECO project on the formation of neuronal networks through neurite outgrowth, axon navigation, synapse formation, and synaptic competition. Applying and further extending existing modeling frameworks created previously within our group and the SECO consortium, we will study the self-construction of neuronal networks (in particular the principles underlying the development of the cortical and thalamic circuitry), and the relationship between neuronal morphology and patterns of synaptic connectivity.
Ideal candidates should combine a strong neurobiological interest with a background in neuro-biophysics and extensive experience in computational modeling and computer programming (C++ and Java). Candidates at Postdoc level are preferred (project durations 2 years), but we may also consider PhD students.
Candidates are expected to contribute significantly to the collaborative effort of the SECO consortium.
For further information about these positions, please contact Dr. Arjen van Ooyen, arjen(dot)van(dot)ooyen(at)cncr(dot)vu(dot)nl, or Dr. Jaap van Pelt, jaap(dot)van(dot)pelt(at)cncr(dot)vu(dot)nl. Application letters including a CV, research experience, a short statement of research interests, and contact details of two referees should be sent by email to Dr. Arjen van Ooyen.
*** Modeling neuronal morphogenesis ***
The position is funded by the NWO Computational Life Sciences project “Neuronal Network Formation through Reciprocal Interactions between Activity and Structure” (NETFORM). The general aim of this project is to investigate the activity-dependent development of neurons and neuronal networks.
In the research line for which a vacancy exists, the focus is on the development of dendritic morphology in single neurons. We will create computational models of neuronal morphogenesis in which cell-type specific dendritic trees develop through neurite elongation and branching as mediated by the behavior of growth cones. A major challenge is to find a balanced level of description of neurite outgrowth based on cellular, biophysical mechanisms, such as cytoskeletal dynamics. The models will be used to study, for example, competitive interactions in neuronal morphogenesis, the impact of electrical activity on neuronal morphology, and the formation of aberrant neuronal morphology in brain diseases.
Ideal candidates should combine a strong neurobiological interest with an excellent background in computational/biophysical modeling. A candidate at Postdoc level is preferred (project duration is 2.5 years), but we may also consider PhD students.
For further information about these positions, please contact Dr. Arjen van Ooyen, arjen(dot)van(dot)ooyen(at)cncr(dot)vu(dot)nl, or Dr. Jaap van Pelt, jaap(dot)van(dot)pelt(at)cncr(dot)vu(d0t)nl. Application letters including a CV, research experience, a short statement of research interests, and contact details of two referees should be sent by email to Dr. Arjen van Ooyen.