The decision about the actual number of active neurons is an open issue in spike sorting, with sparsely firing neurons and background activity the most influencing factors. Dominant-sets clustering algorithm is a graph-theoretical algorithmic procedure that successfully addresses this issue. The quality of grouping in the data is evaluated with the estimation of ‘cohesiveness’, i.e. a cluster-quality measure, for each group.

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Background noise and spike overlap pose problems in contemporary spike-sorting strategies. The (non-linear) isometric feature mapping (ISOMAP) technique reveals the intrinsic data structure and helps with recognising the involved neurons.

To reproduce this tutorial in MATLAB you will need : Read the rest of this entry…

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