LFPy is a Python package for calculation of extracellular potentials from multicompartment neuron models. It relies on the NEURON simulator and uses the Python interface it provides.

LFPy provides a set of easy-to-use Python classes for setting up your model, running your simulations and calculating the extracellular potentials arising from activity in your model neuron. If you have a model working in NEURON already, it is likely that it can be adapted to work with LFPy.

The extracellular potentials are calculated from transmembrane currents in multi-compartment neuron models using the line-source method (Holt & Koch, J Comp Neurosci 1999), but a simpler point-source method is also available. The calculations assume that the neuron are surrounded by an infinite extracellular medium with homogeneous and frequency independent conductivity, and compartments are assumed to be at least at a minimal distance from the electrode (which can be specified by the user). In the present version LFPy is mainly designed for simulation of single neurons.

LFPy is available here: http://compneuro.umb.no/LFPy/

LFPy was developed in the Computational Neuroscience GroupDepartment of Mathemathical Sciences and Technology, at the Norwegian University of Life Sciences , in collaboration with the Laboratory of NeuroinformaticsNencki Institute of Experimental Biology, Warsaw, Poland. The effort was supported by International Neuroinformatics Coordinating Facility (INCF) and the The Research Council of Norway (eScience, NevroNor).

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