Advances in brain-computer interfaces, restorative neurotechnology, and assistive robot technology reported in Nature by the BrainGate2 collaboration of researchers, allowed two people with tetraplegia to reach for and grasp objects in three-dimensional space using robotic arms that they controlled directly with brain activity.

The BrainGate2 pilot clinical trial employs the investigational BrainGate system, initially developed at Brown University, in which a grid of 96 tiny electrodes is implanted in the motor cortex. The electrodes record the neural activity associated with intended movement and an external computer featuring spike sorting algorithms decodes neural activity  into commands to operate assistive devices as the robot arms used in the Nature.

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